Compiled to mark the station's 25th birthday, the list features the top 25 hits from the last 25 years and includes G-Eazy and Carnage's sample of Erik Satie's Gnossienne No. 1, which tops this year's best-selling.
Elsewhere, Muse's sample of Giovanni Pierluigi Da Palestrina's Benedictus features, as well as David Guetta (sampling Ezio Bosso), Dizzee Rascal (sampling Pyotr Ilyich Tchaikovsky) and Lady Gaga (sampling Vittorio Monti).
In a statement on the Classic FM website, presenter John Suchet said: 'This list of hits from the past 25 years is so fantastic because it confirms just how relevant classical music is to our lives. We are on a mission to make classical music accessible to everyone, regardless of age or background.
'A quarter of a century on from our launch, we’re dedicated to breaking down the barriers around classical music and broadening its appeal. These 25 hits reinforce how inspiring and important classical music is to music today.'
Speaking to the station, Professor Green said: 'The world of rap has huge respect for classical music. Myself along with lots of contemporary artists recognise the value and the importance classical music has on our music making and it has often played a big part in my song writing.'
The full list is:
2017: G-EAZY, Carnage and Thirty Rack – Guala (Erik Satie, Gnossienne No.1)
2016: Zayn – Blue (Johann Sebastian Bach, Prelude No.1 in C Major from The Well–Tempered Clavier)
2015: Muse – Drones (Giovanni Pierluigi da Palestrina, Benedictus from Missa Papae Marcelli)
2014: David Guetta – Dangerous (Ezio Bosso, Symphony No.2 ‘Under the Trees’ – 4th movement)
2013: Little Mix – Little Me (Gabriel Fauré, Pavane in F-sharp Minor)
2012: Alicia Keys – Piano Mash Up (Ludwig van Beethoven, Piano Sonata No.14 in C-sharp minor ‘Moonlight’ – 1st Movement)
2011: Dizzee Rascal – Nutcrackerz featuring Giggs (Pyotr Ilyich Tchaikovsky, Dance of the Sugar Plum Fairy from The Nutcracker)
2010: NDubbs and BodyRox – We Dance On (Johann Pachelbel, Canon in D Major)
2009: Lady Gaga – Alejandro (Vittorio Monti, Csárdás)
2008: Beyonce – Ave Maria (Franz Schubert, Ave Maria)
2007: Alicia Keys – As I Am (Frédéric Chopin, Nocturne No. 20 in C-sharp Minor)
2006: Professor Green feat. C.O.R.E and Chynaman – Upper Clapton Dance (Brahms’ Hungarian Dance No. 5 in F-sharp Minor)
2005: Bright Eyes – Road to Joy (Ludwig van Beethoven, Symphony No.9 in D minor – 4th movement ‘Ode to Joy’)
2004: The Farm – All Together Now (Johann Pachelbel, Canon in D major)
2003: Nas – I Can (Ludwig van Beethoven, Bagatelle No.25 in A minor ‘Für Elise’)
2002: The Streets, Same Old Thing (Antonín Dvo?ák, Symphony No.9 in E minor ‘From the New World’ – 1st movement)
2001: Ludacris – Coming 2 America (Wolfgang Amadeus Mozart, ‘Dies Irae’ from the Requiem in D Minor)
2000: S Club 7 – Natural (Gabriel Fauré, Pavane in F-sharp minor)
1999: Puff Daddy – Hate Me Now (Carl Orff, ‘O Fortuna’ from Carmina Burana)
1998: Sweetbox – Everything's Gonna Be Alright (Johann Sebastian Bach, Air on the G String)
1997: Puff Daddy – I’ll be Missing You (Samuel Barber, Agnus Dei)
1996: Celine Dion – All by Myself (Sergei Rachmaninov, Piano Concerto No.2 in C minor – 2nd movement)
1995: Take That – Never Forget (Giuseppe Verdi, ‘Tuba mirum’ from the Requiem Mass)
1994: 2 Unlimited – The Real Thing (Johann Sebastian Bach, Toccata and Fugue in D minor)
1993: UB40 – I Can’t Help Falling in Love with You (Jean-Paul-Égide Martini, Plaisir d'Amour)
1992: Madonna – In This Life (George Gershwin, Prelude No.2 in C-sharp minor)